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 Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), human
  • Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), human
  • Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), human

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    上架时间:2011年08月23日
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    GenScript Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), human was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types,

    Full Name
    Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), human  
    Abbreviated Name-1 rHuGM-CSF
    Abbreviated Name-2 GM-CSF
    Description GenScript Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), human was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. On mature hematopoietic, monocytes/macrophages and eosinophils. It can induce human endothelial cells to migrate and proliferate. Additionally, it can stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma, and adenocarcinoma cell lines.  
    Source E. coli
    M.W. 14,000 Da  
    Purity Greater than 95% as determined by
    (a) Analysis by SEC-HPLC
    (b) Analysis by reducing and non-reducing SDS-PAGE silver-stained gel
    Endotoxin Level Less than 0.03 ng/μg (0.3 IEU/μg) determined by LAL test  
    Specific Activity The specific activity was determined and has been found to be greater than 1.0×107 IU/mg.  
    Storage Lyophilized rHuGM-CSF, although stable at room temperature for three weeks, should be stored desiccated at -18°C or below. Upon reconstitution, rHuGM-CSF may be stored at 4°C for short periods (two to seven days). For long term storage, it is recommended that a carrier protein (0.1% HSA or BSA) be added. Avoid repeated freeze-thaw cycles.  
    Formulation The protein is lyophilized after extensive dialysis against 2 mM sodium phosphate buffer pH=7.4±0.1.  
    Reconstitution It is recommended that the lyophilized rHuGM-CSF be reconstituted in sterile 18 MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.  
    Sequence analysis The sequence of the first fifteen N-terminal amino acids has been found to be (Met)-Ala-Pro-Ala-Arg-Ser-Pro-Ser-Pro-Ser-Thr-Gln-Pro-Trp-Glu-His.