上海经科化学科技有限公司

 Anti-Human Neural/Glial Antigen 2 (NG2) Purified
  • Anti-Human Neural/Glial Antigen 2 (NG2) Purified
  • Anti-Human Neural/Glial Antigen 2 (NG2) Purified

    参考价格: ¥0.00
    适用范围:全领域
    所在地区:
    上架时间:2011年09月18日
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    Anti-Human Neural/Glial Antigen 2 (NG2) PurifiedAlso known as: Chondroitin Sulfate Proteoglycan, MCSP/melanoma chondroitin sulfate proteoglycan Clone: 9.2.27 RUO: For Research Use Only

    Description: This 9.2.27 monoclonal antibody reacts with human neural/glial antigen 2, which is also known as melanoma chondroitin sulfate proteoglycan (MCSP). This antigen is composed of a 250 kDa N-linked glycoprotein and a >450 kDa proteoglycan. NG2 is present on the surface of >90% of malignant melanomas in addition to some non-melanomic tumors. Moreover, NG2 is expressed on glioma cells, as well as on developing and adult oligodendrocyte precursor cells. Studies have demonstrated the involvement of this protein in tumor cell proliferation, adhesion, migration, and invasion. NG2 also functions as a coreceptor for alpha4beta1 integrin. Finally, expression of NG2 can be used as a prognostic marker for disorders such as acral letiginous melanoma and infantile acute myeloid leukemia.

    The 9.2.27 antibody has been reported to suppress melanoma tumor growth.