上海希美化学有限公司

Anti-Human Actin Bundles(Actin Bundles)

Anti-Human Actin Bundles(Actin Bundles)

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Anti-Human Actin Bundles (Actin Bundles)Tissue Culture SupernatantMonoclonal AntibodyProd. No.: A115 Clone: AE-7 Isotype: Mouse IgM Pkg. Size: 2.0 ml

Anti-Human Actin Bundles (Actin Bundles)
Tissue Culture Supernatant
Monoclonal Antibody
Prod. No.:  A115
Clone:      AE-7
Isotype:    Mouse IgM
Pkg. Size:  2.0 ml

Description
Specificity:
Anti-Human Actin Bundles (Clone AE-7) recognizes and antigen associated with human actin bundles. The sequence of the epitope is unmapped.

Background:
Microfilaments (or actin filaments) are the thinnest filaments of the cytoskeleton found in the cytoplasm of all eukaryotic cells. These linear polymers of actin subunits are flexible and relatively strong, resisting buckling by multi-piconewton compressive forces and filament fracture by nanonewton tensile forces. Microfilaments are highly versatile, functioning in (a) actoclampin-driven expansile molecular motors, where each elongating filament harnesses the hydrolysis energy of its "on-board" ATP to drive actoclampin end-tracking motors to propel cell crawling, ameboid movement, and changes in cell shape, and (b) actomyosin-driven contractile molecular motors, where the thin filaments serve as tensile platforms for myosins ATP hydrolysis-dependent pulling action in muscle contraction and uropod advancement.Actin filaments are assembled in two general types of structures: bundles and networks. Actin-binding proteins dictate the formation of either structure since they cross-link actin filaments in the double-stranded helix.

Known Species Cross Reactivity: Hu+
Host Species
Mouse
Formulation
Anti-Human Actin Bundles is supplied in filtered tissue supernatant (RPMI-1640) pH-7.2 containig 0.09% sodium azide.
Storage and Stability
For long term storage freeze working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Products are for research use only. Not for use in diagnostic or therapeutic procedures