上海希美化学有限公司

 Anti-Human Caspase-3 Active Subunit(CASP3)
  • Anti-Human Caspase-3 Active Subunit(CASP3)
  • Anti-Human Caspase-3 Active Subunit(CASP3)

    参考价格: ¥0.00
    适用范围:全领域
    所在地区:
    上架时间:2011年12月16日
    留言咨询
    与企业取得联系时请告知该信息获取自中国教育装备采购网
    我要分享
    详细说明

    Anti-Human Caspase-3 Active Subunit(p17)(CASP3)PurifiedMonoclonal AntibodyProd. No.: C1141 Clone: C31.129 Isotype: Mouse IgG1 Conc.: 0.2 mg/ml Pkg. Size: 0.2 mg Storage: -20°C

    Anti-Human Caspase-3 Active Subunit(p17)(CASP3)Purified
    Monoclonal Antibody
    Prod. No.:  C1141
    Clone:      C31.129
    Isotype:    Mouse IgG1
    Conc.:      0.2 mg/ml
    Pkg. Size:  0.2 mg
    Storage:    -20°C

    Description
    Specificity:
    Anti-Human Caspase-3 Active Subunit (p17) (clone C31.129) recognizes the human 17-20 kDa cleaved active subunit of caspase 3 and does not react with the inactive proenzymes. The antibody was developed using a synthetic peptide with residues mapping to the N-terminus of the (p17) subunit of human caspase 3. The antibody has not been tested for species cross-reactivity or cross reactivity with other caspases.

    Background:
    Caspase-3 is a member of the caspase family of cysteine proteases and plays a key role in mediating Fas (CD95) and tumor necrosis factor–1 (TNFR-1) induced apoptosis. Caspases can be divided into three groups: apoptotic initiators, apoptotic executioners, and inflammatory mediators.1,2 Caspase-3 is activated during apoptotic signaling events by upstream proteases including caspase 6 and caspase 8.3 Caspase-3 is thought to be essential for chromatin margination, DNA fragmentation and nuclear collapse during apoptosis.3

    Known Species Cross Reactivity: Hu+
    Host Species
    Mouse
    Formulation
    This purified antibody is formulated with no preservatives and 1% BSA and 50% glycerol in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl.
    Storage and Stability
    This antibody does not contain preservatives and must be stored at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
    Reported Applications
    WB

    References
    1. Adadah, B. A. et al. (2000) Journal of Neurotoma 17(10): 811
    2. Salvesen, G. S. et al. (1999) Proc. Natl. Acad. Sci. USA 96(20): 10964
    3. Slee, E. A. et al. (2001) J. Biol. Chem. 276(10):7320

    Related Products
    Recombinant Human Pro-Caspase-3 (Leinco Prod. No.: P259)

    Products are for research use only. Not for use in diagnostic or therapeutic procedures