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Anti-Human Caspase-13

Anti-Human Caspase-13

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Rabbit Anti-Human Caspase-13Purified No Carrier Protein(ERICE)Polyclonal AntibodyProd. No.: C1117 Host: Rabbit Conc.: 0.5 mg/ml Pkg. Size: 1 mg, 0.1 mg, 0.5 mg Storage: 2-8°C

Rabbit Anti-Human Caspase-13
Purified No Carrier Protein
(ERICE)
Polyclonal Antibody

Prod. No.: C1117
Host:         Rabbit
Conc.:     0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:      2-8°C

Description
Specificity:
Rabbit Anti-Human Caspase-13 recognizes mouse, rat and human Caspase-13. This polyclonal antibody was purified using affinity chromatography.

Background:
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13.1 Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.1

Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
Caspase-13 Blocking Peptide (Leinco Prod. No.: C1129)
Blocking Peptide
Caspase-13 Blocking Peptide (Leinco Prod. No.: C1129)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB
Western Blotting: This antibody can be used to detect mouse, rat and human Caspase-13 by Western blot analysis at a concentration of 0.5-1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is HL60 Whole Cell Lysate (Leinco Prod. No.: H1403).

References
1. Humke EW, Ni J, Dixit VM. ERICE, a novel FLICE-activatable caspase. J Biol Chem 1998;273:15702-7 (WD0500)
Related Products
Caspase-13 Blocking Peptide (Leinco Prod. No.: C1129)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
HL60 Whole Cell Lysate (Leinco Prod. No.: H1403)
PN:

Products are for research use only. Not for use in diagnostic or therapeutic procedures.