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 Anti-Human Caspase-13
  • Anti-Human Caspase-13
  • Anti-Human Caspase-13

    参考价格: ¥0.00
    适用范围:全领域
    所在地区:
    上架时间:2011年12月16日
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    Rabbit Anti-Human Caspase-13Purified No Carrier Protein(ERICE)Polyclonal AntibodyProd. No.: C1117 Host: Rabbit Conc.: 0.5 mg/ml Pkg. Size: 1 mg, 0.1 mg, 0.5 mg Storage: 2-8°C

    Rabbit Anti-Human Caspase-13
    Purified No Carrier Protein
    (ERICE)
    Polyclonal Antibody

    Prod. No.: C1117
    Host:         Rabbit
    Conc.:     0.5 mg/ml
    Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
    Storage:      2-8°C

    Description
    Specificity:
    Rabbit Anti-Human Caspase-13 recognizes mouse, rat and human Caspase-13. This polyclonal antibody was purified using affinity chromatography.

    Background:
    Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13.1 Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.1

    Known Species Cross Reactivity: Ms+, Hu+, Rt+
    Immunogen
    Caspase-13 Blocking Peptide (Leinco Prod. No.: C1129)
    Blocking Peptide
    Caspase-13 Blocking Peptide (Leinco Prod. No.: C1129)
    Formulation
    This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
    Storage and Stability
    This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
    Reported Applications
    IHC (NBF/Par.), WB
    Western Blotting: This antibody can be used to detect mouse, rat and human Caspase-13 by Western blot analysis at a concentration of 0.5-1.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is HL60 Whole Cell Lysate (Leinco Prod. No.: H1403).

    References
    1. Humke EW, Ni J, Dixit VM. ERICE, a novel FLICE-activatable caspase. J Biol Chem 1998;273:15702-7 (WD0500)
    Related Products
    Caspase-13 Blocking Peptide (Leinco Prod. No.: C1129)
    Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
    HL60 Whole Cell Lysate (Leinco Prod. No.: H1403)
    PN:

    Products are for research use only. Not for use in diagnostic or therapeutic procedures.