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Anti-Human Caspase-8(CT)

Anti-Human Caspase-8(CT)

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Rabbit Anti-Human Caspase-8Purified No Carrier Protein(FLICE, MACH, Mch5, CASP8, CAP4, MGC78473)Polyclonal AntibodyProd. No.: C1240 Host: Rabbit Conc.: 0.5 mg/ml Pkg. Size: 1 mg, 0.1 mg, 0.5 mg Storage: 2-8°C

Rabbit Anti-Human Caspase-8
Purified No Carrier Protein
(FLICE, MACH, Mch5, CASP8, CAP4, MGC78473)
Polyclonal Antibody

Prod. No.: C1240
Host:          Rabbit
Conc.:      0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:       2-8°C

Description
Specificity:
Rabbit Anti-Human Caspase-8 recognizes an epitope near the C-terminuse of mouse, rat and human Caspase-8. This polyclonal antibody was purified using affinity chromatography.

Background:
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.1,2 The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death.3 Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex.4 The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation.5 FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.6

caspase-8 presents a promising target to restore defective apoptosis programs in cancers in order to overcome resistance.

Known Species Cross Reactivity: Ms+, Hu+, Rt+
Immunogen
Purified Recombinant Human Caspase-8 (>98%)
Blocking Peptide
Caspase-8 (CT) Blocking Peptide (Leinco Prod. No.: C1277)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
IHC (NBF/Par.), WB

References
1. Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

2. Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.

3. Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.

4. Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996; 85:817-27.
Related Products
Caspase-8 (CT) Blocking Peptide (Leinco Prod. No.: C1277)
Anti-Human Caspase-8 (Intermediate Domain) (Leinco Prod. No.: C1241)
Caspase-8 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: C1278)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.