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Rabbit Anti-Human DR3

Rabbit Anti-Human DR3

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Rabbit Anti-Human Death Receptor 3(DR3)Purified No Carrier Protein(Wsl-1, Apo-3, TRAMP, LARD)Polyclonal AntibodyProd. No.: D283 Host: Rabbit Conc.: 0.5 mg/ml Pkg. Size: 1mg, 0.1mg, 0.5mg Storage: 2-8°C

Rabbit Anti-Human Death Receptor 3(DR3)
Purified No Carrier Protein
(Wsl-1, Apo-3, TRAMP, LARD)
Polyclonal Antibody
Prod. No.:  D283
Host:       Rabbit
Conc.:      0.5 mg/ml
Pkg. Size:  1mg, 0.1mg, 0.5mg
Storage:    2-8°C

Description
Specificity:
Rabbit Anti-Human Death Receptor 3 (DR3) recognizes Human DR3. This polyclonal antibody was purified using DEAE chromatography.

Background:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-κB activation.

Known Species Cross Reactivity: Ms+, Hu+
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB
Western Blotting: To detect Human DR3 this polyclonal antibody can be used at a dilution range of 1:500 to 1:1000. This polyclonal antibody should be used in conjunction with compatible second-step reagents such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190) and a chromogenic substrate such as TMB HRPO Membrane/IHC Substrate UltraSensitive™ One Component "Ready Use" (Leinco Prod. No.: T343). The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used.

Related Products
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
TMB HRPO Membrane/IHC Substrate UltraSensitive™ One Component "Ready Use" (Leinco Prod. No.: T343)
Anti-Human DR3/TNFRSF25 (Antigen Aff. Pur.) (Leinco Prod. No.: D351)

Products are for research use only. Not for use in diagnostic or therapeutic procedures