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 Anti-Human MMP-13
  • Anti-Human MMP-13
  • Anti-Human MMP-13

    参考价格: ¥0.00
    适用范围:全领域
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    上架时间:2011年12月21日
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    Anti-Human Matrix Metalloproteinase-13(MMP-13)Purified No Carrier Protein(Collagenase 3, CLG3, CL3)Monoclonal AntibodyProd. No.: M1088 Clone: M31.387 Isotype: Mouse IgG1 Conc.: 0.1 mg/ml Pkg. Size: 0.2 mg Storage: 2-8°C

    Anti-Human Matrix Metalloproteinase-13(MMP-13)
    Purified No Carrier Protein
    (Collagenase 3, CLG3, CL3)
    Monoclonal Antibody
    Prod. No.:  M1088
    Clone:      M31.387
    Isotype:    Mouse IgG1
    Conc.:      0.1 mg/ml
    Pkg. Size:  0.2 mg
    Storage:    2-8°C

    Description
    Specificity:
    Anti-Human MMP-13 (clone M31.387) was produced in mice using a synthetic peptide corresponding to amino acids 131 to 140 of human MMP-13. This antibody recognizes the approximately 54-60 kDa latent human MMP-13.

    Background:
    Matrix metallopeptidase 13 (collagenase 3), also known as MMP13, is a glycosylated protein1 and a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, which is expressed in the skeleton during embryonic development2 and are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP-13 is tightly bound to tissues and utilizes heparan sulfate proteoglycans as extracellular docking molecules. It is produced by many different cell types as an inactive proform that requires proteolytic activation to gain activity.3 Mutations causing lack of MMP-13 expression have been shown to be associated with skeletal disorders characterized by defective growth and modeling of the spine and long bones (spondyloepimetaphyseal dysplasias).4

    Known Species Cross Reactivity: Hu+
    Host Species
    Mouse
    Immunogen
    a synthetic peptide corresponding to amino acids 131 to 140 of human MMP-13
    Formulation
    This purified antibody is formulated with no carrier proteins or preservatives added in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl.
    Storage and Stability
    The antibody should be stored at -20°C. Avoid repeated freezing and thawing. This product does not contain preservatives.
    Reported Applications
    WB

    References
    1. Knäuper V et al. (1996) J Biol. Chem. 271: 17124
    2. Stephen M. Krane et al. (2004) National Acad. Scien.
    3. Woessner JF. et al. (2000) J Biol. Chem. 275: 4183
    4. Kennedy AM. et al. (2005) J Clin. Invest. 115: 2832

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    Products are for research use only. Not for use in diagnostic or therapeutic procedures