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Anti-Human Phosphodiesterase V(PDE-5)

Anti-Human Phosphodiesterase V(PDE-5)

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Anti-Human Phosphodiesterase V(Phosphodiesterase V)Purified(PDE-5)Monoclonal AntibodyProd. No.: P164 Clone: 29.29 Isotype: Mouse IgG1 Conc.: 0.5mg/ml Pkg. Size: 0.1mg Storage: 2-8°C

Anti-Human Phosphodiesterase V(Phosphodiesterase V)Purified
(PDE-5)
Monoclonal Antibody
Prod. No.:  P164
Clone:      29.29
Isotype:    Mouse IgG1
Conc.:      0.5mg/ml
Pkg. Size:  0.1mg
Storage:    2-8°C

Description
Specificity:
Mouse Anti-Human Phosphodiesterase V (Phosphodiesterase V) (Clone 29.29) recognizes an epitope on Human Phosphodiesterase V. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background:
Phosphodiesterases (PDEs) are a superfamily of enzymes that degrade the intracellular second messengers cyclic AMP and cyclic GMP. These enzymes are essential regulators of cyclic nucleotide signaling with diverse physiological functions. PDEs are drug targets for the treatment of disease states including heart failure, depression, asthma, inflammation and erectile dysfunction. Of the 12 PDE gene families, cGMP specific PDE5 carries out the principal cGMP hydrolyzing activity.1,2

Known Species Cross Reactivity: Hu+
Host Species
Mouse
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Stability
This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
WB

Country of Origin
USA
References
1. Piazza, Gary, et al. (2001) Cancer Research 61:3961-3968
2. Sung, Byung-Je et al. (1002) Nature 425:98-102

Products are for research use only. Not for use in diagnostic or therapeutic procedures