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Anti-Human Mcl-1(CT)

Anti-Human Mcl-1(CT)

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Rabbit Anti-Human Mcl-1Purified No Carrier Protein(Myeloid Cell Leukemia-1)Polyclonal AntibodyProd. No.: M1211 Host: Rabbit Conc.: 0.5 mg/ml Pkg. Size: 1 mg, 0.1 mg, 0.5 mg Storage: 2-8°C

Rabbit Anti-Human Mcl-1
Purified No Carrier Protein
(Myeloid Cell Leukemia-1)
Polyclonal Antibody

Prod. No.: M1211
Host:         Rabbit
Conc.:      0.5 mg/ml
Pkg. Size: 1 mg, 0.1 mg, 0.5 mg
Storage:      2-8°C

Description
Specificity:
Anti-Human Mcl-1(CT)
Rabbit Anti-Human Mcl-1 recognizes an epitope near the C-terminus of Human, Mouse and Rat Mcl-1. This polyclonal antibody was purified using affinity chromatography.

Background:

Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival (reviewed in 1). While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak.2,3 Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals.3 Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Known Species Cross Reactivity: Ms+, Hu+, Rt+

Immunogen
Mcl-1 (CT) Blocking Peptide (Leinco Prod. No.: M1215)
Blocking Peptide
Mcl-1 (CT) Blocking Peptide (Leinco Prod. No.: M1215)
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Storage and Stability
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Reported Applications
Anti-Human Mcl-1(CT)
IHC (NBF/Par.), WB, In vivo Depletion
Western Blotting: This antibody can be used to detect Human, Mouse and Rat Mcl-1 by Western blot analysis at a concentration of 1.0-2.0 µg/ml when used in conjunction with compatible secondary reagents, such as Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190), under either reducing or non-reducing conditions. The positive control for Western blotting is Raji Whole Cell Lysate (Leinco Prod. No.: R1009).

References
1. Edwards, S. W. et al. (2004) Biochem Soc Trans. 32:489
2. Cuconati, A. et al. (2003) Genes and Dev. 17:2922
3. Kozopas, K. M. et al. (1993) Proc. Natl. Acad. Sci. USA 90:3516
Related Products
Mcl-1 (CT) Blocking Peptide (Leinco Prod. No.: M1215)
Goat Anti-Rabbit IgG (H&L)-Horseradish Peroxidase (Leinco Prod. No.: R1190)
Raji Whole Cell Lysate (Leinco Prod. No.: R1009)
Anti-Human Mcl-1 (Intermediate Domain) (Leinco Prod. No.: M1212)
Anti-Human Mcl-1 (NT) (Leinco Prod. No.: M1213)
Mcl-1 (Intermediate Domain) Blocking Peptide (Leinco Prod. No.: M1216)
Mcl-1 (NT) Blocking Peptide (Leinco Prod. No.: M1217)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.