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Recombinant Human IL-18 Rα

Recombinant Human IL-18 Rα

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详细说明

Recombinant Human Interleukin-18 Receptor Alpha (IL-18 Rα)Purified No Carrier Protein(IL18R1, CDw218a, IL-1Rrp, IL1RRP)Prod. No.: I-591 Source NSO Cells Pkg. Size: 1 mg, 100 μg Storage: -20°C to -70°C

Recombinant Human Interleukin-18 Receptor Alpha (IL-18 Rα)
Purified No Carrier Protein
(IL18R1, CDw218a, IL-1Rrp, IL1RRP)
Prod. No.: I-591
Source NSO Cells
Pkg. Size: 1 mg, 100 µg
Storage: -20°C to -70°C

Description
Background:

The interleukin-18 receptor 1 (IL-18R1) is a cytokine receptor of the immunoglobulin superfamily. IL18R1 is also known as IL-18Rα, CDw218a (cluster of differentiation w218a), IL-1Rrp, and IL-1R family member. IL-18R1 specifically binds to interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL-18Rα is expressed on Th1 cells, NK cell subset, neutrophils and IL-12-stimulated tonsillar B cells. By itself, IL-18Rα binds IL-18 with low affinity and when complexed with IL-18Rβ chain binds IL-18 with high affinity. The proinflammatory cytokine IL-18 and its receptor complex play an important role in the innate and autoimmune responses.

Source
NSO Cells
Molecular Weight
The predicted molecular weight of Recombinant Human IL-18 Rα is Mr 63 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 95-105 kDa.
State of Matter
Lyophilized
Formulation
This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Purity
>95% by SDS-PAGE and analyzed by silver stain.
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Endotoxin
<1.0 EU/µg as determined by the LAL method
Amino Acid Sequence

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