上海易利生物科技有限公司

 3-异丁基-1-甲基黄嘌呤
  • 3-异丁基-1-甲基黄嘌呤
  • 3-异丁基-1-甲基黄嘌呤

    参考价格: ¥0.00
    品  牌:amresco
    产品型号:FK32495
    所在地区:上海
    上架时间:2014年04月26日
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    FK32495 3-异丁基-1-甲基黄嘌呤 99% 1g
    99% 250mg
    Cas号 28822-58-4
    MDL:
    --MFCD00005584
    Beilstein 247859
    EINECS:
    --249-259-3
    分子式 C10H14N4O2
    分子量 222.24
    别名 IBMX;
    1-甲基-3-异丁基黄嘌呤;
    3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮;
    3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮;
    分子结构式 3-异丁基-1-甲基黄嘌呤
    性状 几乎不溶于水,溶于乙醇,2-丙醇。
      IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists.
    备注: 以上描述,仅作参考,并不表示您收到的产品,与此项描述完全相符,产品的出厂标准,请参见质量标准。
    贮存 储存温度-20°C
    用途 cAMP 和 cGMP 磷酸二脂酶的非专一性抑制剂。IBMX抑制了磷酸二脂酶,cAMP的增加激活了PKA ,其结果是减少增殖,增加分化和诱发凋亡. IBMX抑制由苯肾上腺素诱导的色胺(来自于神经内分泌上皮细胞的减少粘液IC50: 1.3 μM)的减少 。也作为腺苷受体拮抗剂。
    生化和生理学机理 Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.
    3-异丁基-1-甲基黄嘌呤