南京赛泓瑞生物科技有限公司

 G-CSF粒细胞激落刺激因子
  • G-CSF粒细胞激落刺激因子
  • G-CSF粒细胞激落刺激因子

    参考价格: ¥0.00
    产品型号:ELISA_Kits
    所在地区:江苏
    上架时间:2012年09月21日
    留言咨询
    与企业取得联系时请告知该信息获取自中国教育装备采购网
    我要分享
    详细说明

    粒细胞激落刺激因子


    Synonym Names for CSF3 protein: CSF3; GCSF; G-CSF, Human, Recombinant, E Coli; G-CSF; Pluripoietin; Filgrastim; Lenograstim; Granulocyte colony-stimulating factor

    Human granulocyte colony-stimulating factor (hG-CSF) is one of the hematopoietic growth factors which plays an important role in stimulating proliferation, differentiation, and functional activation of blood cells.
    In addition to its effect on hematopoiesis, G-CSF also enhances neutrophil functions against bacteria, fungi, and tumor cells mediated by antibody-dependent cell-mediated cytotoxicity.
    Recombinant hG-CSF was expressed in E.coli and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer

    Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

    Subunit: Monomer.

    Subcellular Location: Secreted.

    Ptm: O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).

    Pharmaceutical: Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood).

    Similarity: Belongs to the IL-6 superfamily.

    G-CSF reacts with the proliferative activity of rhg-csf is tested in culture using mouse bone marrow cells..