名称：原装订购| Recombinant Human sIL-4Rα
Source: HEK293 cells. IL-4 can signal through type I and type II receptor complexes, which share a common γ chain (γc).
Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity.
Description: The type I receptor contains in addition to the γ chain an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα. The ED50 was determined by its ability to inhibit the IL-4 dependent proliferation of human TF-1 cells is ≤ 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4), It plays an important role in regulating the differentiation of naive CD4+ T cells and class switching to IgG1 and IgE.