名称：原装供应| Recombinant Human WNT-1
Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues. Source: E.coli. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenin. Cross Reactivity: Mouse.
Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. The ED50 was determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. The expected ED50 for this effect is 1.5 - 2.5 ng/ml in the presence of 200 ng/ml of human BMP-2.
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