名称：原装精品| Recombinant Murine NOGGIN
Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Country of Origin: USA. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin.
Description: The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, Source: E.coli. Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. in which cellular response can vary considerably depending upon the local concentration of the signaling molecule.
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