名称：精品原装| Recombinant Human TWEAK Receptor
Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml. TWEAKR belongs to the TNF family of transmembrane proteins and contains a cytoplasmic "death domain", which can activated the cells apoptotic machinery.
Source: E.coli. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Country of Origin: USA.
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