名称：精品原装| Recombinant Rat TNF-α
Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 5 x 107 units/mg. TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts.
Source: E.coli. Recombinant rat TNF-α is a soluble 157 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. Cross Reactivity: Mouse.
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