Storage:Store at -20°C.
Solubility:Soluble in water.
Sequence:XFASYXLRPA (Modifications: X-1 = D-2-Nal and N-terminal Ac, Phe-2 = D-(4-Cl-Phe), Ala-3 = D-(3-Pyridyl-Ala), X-6 = D-Cit, Ala-10 = D-Ala and C-terminal amide).
Exhibits antiproliferative effects and displays efficacy against hormone-sensitive cancers in vivo. Suppresses production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which inhibits ovulation. Potent gonadotrophin-releasing hormone (GnRH) receptor antagonist (KD = 0.202 nM, IC50 = 1.21 nM).
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