上海叶舟生物科技有限公司

 p53 (1C12) Mouse mAb
  • p53 (1C12) Mouse mAb
  • p53 (1C12) Mouse mAb

    参考价格: ¥1600.00
    品  牌:CST
    产品型号:2524 (100ul)
    所在地区:上海
    上架时间:2012年09月27日
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    p53 (1C12) Mouse mAb
    名称:现货供应|p53 (1C12) Mouse mAb
    货号:2524
    规格:100ul
    产地:CST
    Source / Purification
    Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability, and activity. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser20 of human p53. Phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and activation of p53 in response to DNA damage .
    Specificity / Sensitivity
    DNA damage induces phosphorylation of p53 at Ser15 and Ser20 and leads to a reduced interaction between p53 and its negative regulator, the oncoprotein MDM2. p53 (1C12) Mouse mAb detects endogenous levels of total p53 protein. MDM2 inhibits p53 accumulation by targeting it for ubiquitination and proteasomal degradation.