Storage: Store at or below -20 ºC.
Solubility: Soluble in DMSO.
M.I. 14: 8251
View the MSDS for this product
Parker, C.A., et al. "Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4." Rolipram suppressed cardiopulmonary bypass-induced systemic inflammatory response syndrome, probably through the regulation of proinflammatory mediators by inhibiting phosphodiesterase type 4.
Synapse 55: 270-279 (2005). Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor. PDE4 enzymes inactivate cyclic AMP (cAMP) via hydrolysis to 5-AMP. R-(-)-rolipram demonstrated a higher affinity for the PDE4 enzyme than S-(+)-rolipram, by about 8-fold in vitro and about 12- to 15-fold in vivo.
Rolipram has two enantiomeric forms, R(-) and S(+). This product is the racemic mixture of the two enantiomers. Hamamoto, M., et al. "Suppressive effect of phosphodiesterase type 4 inhibition on systemic inflammatory responses after cardiopulmonary bypass." J. Artif. Organs 9: 144-148 (2006). Rolipram reduced the initial and late response to ovalbumin (OVA) in isolated strips of guinea-pig colonic smooth muscle.