上海叶舟生物科技有限公司

Brefeldin A

Brefeldin A

参考价格:¥5004.00
品  牌:LC
产品型号:B-8500 (100 mg)
所在地区:华东 上海
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Brefeldin A
名称:原装进口| Brefeldin A
产地:LC
货号:B-8500
规格:100 mg
价格:5004
储存温度说明
Storage:  Store at or below -20 ºC. 
Solubility:  Soluble in DMSO at 100 mg/mL; soluble in ethanol at 25 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A. Brefeldin A, >99%. M.W. 280.36 C16H24O. Warning:  Toxic.
产品其它相关介绍:
View the MSDS for this product
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle.
Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation.  Misumi, Y., et al.  "Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes."  J. Biol. Chem. 261:  11398-11403 (1986). "The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death." Guo, H., et al.  "Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2."  Exp. Cell Res. 245:  57-68 (1998).
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Brefeldin A