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Canertinib, Dihydrochloride Salt

Canertinib, Dihydrochloride Salt

参考价格:¥3942.00
品  牌:LC
产品型号:C-1201 (200 mg)
所在地区:华东 上海
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Canertinib, Dihydrochloride Salt
名称:原装进口| Canertinib, Dihydrochloride Salt
产地:LC
货号:C-1201
规格:200 mg
价格:3942
储存温度说明
Storage:  Store at or below -20 ºC. 
Solubility:  Soluble in DMSO at 100 mg/mL; soluble in ethanol at 1 mg/mL with warming; soluble in water at 10 mg/mL with warming; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Compound is somewhat unstable in HPLC sample solution at room temperature.  Disposal:  A. Canertinib, Dihydrochloride Salt, >99%. M.W. 558.86 C24H25ClFN5O3•2HCl.
产品其它相关介绍:
View the MSDS for this product
Fauci, A.S. and Challberg, M.D.  "Host-based antipoxvirus therapeutic strategies: turning the tables."  J. Clin. Invest. 115:  231-233 (2005). It selectively inhibits erbB1 (epidermal growth factor receptor), erbB2, erbB3, and erbB4 without blocking tyrosine kinase activity of many other receptors such as platelet-derived growth factor receptor, fibroblast growth factor receptor, and insulin receptor. Prevents smallpox viral replication in vitro and inhibits smallpox viral infection in vivo. 
Increases the effectiveness of radiation therapy.  Nyati, M.K., et al.  Canertinib (CI-1033, PD 183805) is a pan-erbB tyrosine kinase inhibitor.  "Radiosensitization by pan ErbB inhibitor CI-1033 in vitro and in vivo."  Clin Cancer Res. 10:  691-700 (2004). Slichenmyer, W.J., et al.  "CI-1033, a pan-erbB tyrosine kinase inhibitor."  Semin. Oncol. 28:  80-85 (2001).
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Canertinib, Dihydrochloride Salt