上海叶舟生物科技有限公司

 Gefitinib, Free Base
  • Gefitinib, Free Base
  • Gefitinib, Free Base

    参考价格: ¥17550.00
    品  牌:LC
    产品型号:G-4408 (25 g)
    所在地区:上海
    上架时间:2012年09月27日
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    Gefitinib, Free Base
    名称:原装进口| Gefitinib, Free Base
    产地:LC
    货号:G-4408
    规格:25 g
    价格:17550
    储存温度说明
    Storage:  Store at or below -20 ºC. 
    Solubility:  Soluble in DMSO, up to about 100 mg/mL; very poorly soluble in water or ethanol.  Disposal:  A. Gefitinib, Free Base, >99%.
    产品其它相关介绍:
    View the MSDS for this product
    It has been shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways in gefitinib-sensitive non-small cell lung cancers. The IC50 values for gefitinib for inhibiting HT-29 and LoVo cell growth were 23.6 - >100 µM and 7.3 - 48.5 µM, respectively, when the exposure times are from 18 hours to 3 days.
    The functions of the EGFR tyrosine kinase in activating the Ras signal transduction cascade and malignant cell growth are thus inhibited. Gefitinib was found to be a potent inhibitor of EGFR kinase (Ki = 0.40 nM), but much weaker against ErbB-2 kinase (Ki = 870 nM) and ErbB-4 kinase (Ki = 1.1 µM).  EGFR tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme. 
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    Gefitinib, Free Base