Storage: Store at or below -20 ºC.
Solubility: Soluble in DMSO at 200 mg/mL; soluble in ethanol at 12 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Iniparib, 99%. Disposal: A.
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PARP1 plays an important role in the repair of DNA damage in cells that occurs naturally or that is induced by DNA-damaging chemotherapy. Mendeleyev, J., et al. "Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide. Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture." Biochem. Pharmacol. 50: 705-714 (1995).
Iniparib had significant antitumor activity in vitro and in vivo, either alone or in combination with chemotherapy in preclinical studies. Iniparib, also known as BSI-201, is a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP1). Iniparib was reduced transiently to 4-iodo-3-nitrosobenzamide by tumor cells at a very low rate, which inhibited PARP by zinc ejection and killed tumor cells.