上海叶舟生物科技有限公司

 Iniparib  原装订购
  • Iniparib  原装订购
  • Iniparib 原装订购

    参考价格: ¥5688.00
    品  牌:LC
    产品型号:I-5432 (2 g)
    所在地区:上海
    上架时间:2012年09月27日
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    Iniparib  原装订购
    名称:原装进口| Iniparib
    产地:LC
    货号:I-5432
    规格:2 g
    价格:5688
    储存温度说明
    Storage:  Store at or below -20 ºC. 
    Solubility:  Soluble in DMSO at 200 mg/mL; soluble in ethanol at 12 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Iniparib, 99%. Disposal:  A.
    产品其它相关介绍:
    View the MSDS for this product:
    PARP1 plays an important role in the repair of DNA damage in cells that occurs naturally or that is induced by DNA-damaging chemotherapy. Mendeleyev, J., et al.  "Potential chemotherapeutic activity of 4-iodo-3-nitrobenzamide.  Metabolic reduction to the 3-nitroso derivative and induction of cell death in tumor cells in culture."  Biochem. Pharmacol. 50:  705-714 (1995).
    Iniparib had significant antitumor activity in vitro and in vivo, either alone or in combination with chemotherapy in preclinical studies. Iniparib, also known as BSI-201, is a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP1). Iniparib was reduced transiently to 4-iodo-3-nitrosobenzamide by tumor cells at a very low rate, which inhibited PARP by zinc ejection and killed tumor cells.
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    Iniparib  原装订购