上海叶舟生物科技有限公司

 Nilotinib, Free Base
  • Nilotinib, Free Base
  • Nilotinib, Free Base

    参考价格: ¥3564.00
    品  牌:LC
    产品型号:N-8207 (500 mg)
    所在地区:上海
    上架时间:2012年09月27日
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    Nilotinib, Free Base
    名称:原装进口| Nilotinib, Free Base
    产地:LC
    货号:N-8207
    规格:500 mg
    价格:3564
    储存温度说明
    Storage:  Store at or below -20 ºC.  Solubility: 
    Soluble in DMSO at 50 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A. Nilotinib, Free Base, >99%.
    产品其它相关介绍:
    View the MSDS for this product:
    Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants.  "Activity of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells." Leuk. Res. 30:  1499-1505 (2006).
    Nilotinib was as potent as imatinib in inducing apoptosis (IC50 = 0.54 nM) and inhibiting proliferation (IC50 = 0.20 nM) of EOL-1 cells.  Nilotinib is under investigation as a possible treatment for the patients with chronic myelogenous leukemia (CML). Verstovsek, S., et al. Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. 
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    Nilotinib, Free Base