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 Olaparib  原装订购
  • Olaparib  原装订购
  • Olaparib 原装订购

    参考价格: ¥5796.00
    品  牌:LC
    产品型号:O-9201 (100 mg)
    所在地区:上海
    上架时间:2012年09月27日
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    Olaparib  原装订购
    名称:原装进口| Olaparib
    产地:LC
    货号:O-9201
    规格:100 mg
    价格:5796
    储存温度说明
    Storage:  Store at or below -20 ºC. 
    Solubility:  Soluble in DMSO at 33 mg/mL; soluble in ethanol at 1.7 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. Olaparib, >99%. Disposal:  A.
    产品其它相关介绍:
    View the MSDS for this product:
    Evers, B., et al.  "Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin."  Clin. Cancer Res. 14:  3916-3925 (2008). Other CAS numbers previously assigned to olaparib, namely 894104-70-2, 937799-91-2, and 1021843-02-6, have been deleted by CAS and are no longer in use.
    Olaparib is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor and an anti-cancer drug being tested in patients with mutations in the genes BRCA1 or BRCA2. Olaparib inhibited the growth of BRCA2-deficient versus BRCA2-proficient mammary tumor cells. Long-term treatment with olaparib caused the development of drug resistance, which was induced by up-regulation of Abcb1a/b genes encoding P-glycoprotein efflux pumps.
     Combination treatment of olaparib and cisplatin had a synergistic cytotoxicity against BRCA2-deficient cells but not against BRCA2-proficient control cells. 
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    Olaparib  原装订购