上海叶舟生物科技有限公司

 OSU-03012, Hydrochloride Salt
  • OSU-03012, Hydrochloride Salt
  • OSU-03012, Hydrochloride Salt

    参考价格: ¥3402.00
    品  牌:LC
    产品型号:O-5679 (25 mg)
    所在地区:上海
    上架时间:2012年09月27日
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    OSU-03012, Hydrochloride Salt
    名称:原装进口| OSU-03012, Hydrochloride Salt
    产地:LC
    货号:O-5679
    规格:25 mg
    价格:3402
    储存温度说明
    Storage:  Store at or below -20 ºC. OSU-03012, Hydrochloride Salt, >99%. Solubility:  Soluble in DMSO.  Disposal:  A.
    产品其它相关介绍:
    View the MSDS for this product:
    OSU-03012 inhibited both recombinant 3-phosphoinositide-dependent kinase-1 activity and PC-3 cell viability with similar IC50 values of ~5 µM. Inhibitor of phosphoinositide-dependent kinase-1. OSU-03012 showed no increased resistance in the mutant cells Ba/F3p210E255K and Ba/F3p210T315I, with an IC50 of 5 µM irrespective of mutations.
    The dose of OSU-03012 to induce 50% chronic lymphocytic leukemia cell death (LC50) at 24 hours was 7.1 µM. OSU-03012 blocked phosphorylated Akt (P-Akt) and its downstream signalling through 4E binding protein and glycogen synthase kinase at concentrations well below that of celecoxib.
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    OSU-03012, Hydrochloride Salt