上海叶舟生物科技有限公司

 Pemetrexed, Disodium Salt, Heptahydrate
  • Pemetrexed, Disodium Salt, Heptahydrate
  • Pemetrexed, Disodium Salt, Heptahydrate

    参考价格: ¥8370.00
    品  牌:LC
    产品型号:P-7177 (5 g)
    所在地区:上海
    上架时间:2012年09月27日
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    Pemetrexed, Disodium Salt, Heptahydrate
    名称:原装进口| Pemetrexed, Disodium Salt, Heptahydrate
    产地:LC
    货号:P-7177
    规格:5 g
    价格:8370
    储存温度说明
    Storage:  Store at or below -20 ºC. 
    Solubility:  Very poorly soluble in DMSO; very poorly soluble in ethanol; soluble in water at 100 mg/mL; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A. Pemetrexed, Disodium Salt, Heptahydrate, >99%.
    产品其它相关介绍:
    View the MSDS for this product
    Shih, C., et al.  "LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes."  Cancer Res. 57:  1116-1123 (1997). Pemetrexed inhibits the proliferation of various human tumor cell lines, including CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells.
    We note that one of our competitors, HouLi Biochem, as of August 16, 2011, is claiming 100% purity for their Pemetrexed, Disodium Salt, Heptahydrate.  This claim is not credible because it is physically impossible.
    Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7 nM, 109 nM and 9.3 µM, respectively. The addition of folic acid supplementation with some antifolates substantially diminished the host toxicity.
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    Pemetrexed, Disodium Salt, Heptahydrate