上海叶舟生物科技有限公司

 PIK-90, Free Base
  • PIK-90, Free Base
  • PIK-90, Free Base

    参考价格: ¥1116.00
    品  牌:LC
    产品型号:P-9050 (5 mg)
    所在地区:上海
    上架时间:2012年09月27日
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    PIK-90, Free Base
    名称:原装进口| PIK-90, Free Base
    产地:LC
    货号:P-9050
    规格:5 mg
    价格:1116
    储存温度说明
    Storage:  Store at or below -20 ºC. 
    Solubility:  Soluble in DMSO at 0.5 mg/mL with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-50 µM buffers, serum, or other additives may increase or decrease the aqueous solubility. PIK-90, Free Base, >99%. Disposal:  A.
    产品其它相关介绍:
    View the MSDS for this product
    Niedermeier, M., et al.  "Isoform-selective phosphoinositide 3-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach."  Blood 113:  5549-5557 (2009). Our PIK-90 product, whose CAS number appears above, is the free base.  The CAS number of the hydrochloride salt is 677338-13-5.
    Combining PIK-90 and the mTORC1 inhibitor rapamycin induced a profound cell cycle arrest, which is similiar to PI-103 treatment alone. PIK-90 is a class I p110α inhibitor (IC50 = 11 nM).  It also blocks p110γ (IC50 = 18 nM), and to a lesser extent p110δ (IC50 = 58 nM) and p110β (IC50 = 350 nM). PIK-90 induced the proliferative arrest of a panel of glioma cell lines. 
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