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 Ruxolitinib, Phosphate Salt
  • Ruxolitinib, Phosphate Salt
  • Ruxolitinib, Phosphate Salt

    参考价格: ¥4284.00
    品  牌:LC
    产品型号:R-6688 (50 mg)
    所在地区:上海
    上架时间:2012年09月27日
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    Ruxolitinib, Phosphate Salt
    名称:原装进口| Ruxolitinib, Phosphate Salt
    产地:LC
    货号:R-6688
    规格:50 mg
    价格:4284
    储存温度说明
    Storage:  Store at or below -20 ºC. 
    Solubility:  Soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol; soluble in water at 8 mg/mL with warming; buffers, serum, or other additives may increase or decrease the aqueous solubility. Ruxolitinib, Phosphate Salt, >99%. Disposal:  A.
    产品其它相关介绍:
    View the MSDS for this product
    Ruxolitinib, also known as INCB18424, is a potent and selective Janus kinase JAK1 and JAK2 inhibitor, with IC50s of 2.7 and 4.5 nM, respectively. Ruxolitinib inhibited JAK1 and JAK2, with IC50 values of 5.9 nM and 5.7 nM, respectively.  It inhibited IL-6 and IL-23 effects at concentrations less than 50 nM. The phosphate salt form of ruxolitinib is used for some or all ruxolitinib formulations for use in humans.
    Quintás-Cardama, A., et al.  "Preclinical characterization of the selective JAK1/2 inhibitor INCB018424:  therapeutic implications for the treatment of myeloproliferative neoplasms."  Blood 115:  3109-3117 (2010). Ruxolitinib inhibited phosphorylated signal transducer and activator of transcription 3 (STAT3) in patients with wild-type JAK2 and in patients with the JAK2 V617F mutation.
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