名称：原装进口| Selumetinib, Free Base
Storage: Store at or below -20 ºC.
Solubility: Soluble in DMSO at 200 mg/mL; soluble in ethanol at 2.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Selumetinib, Free Base, >99%. Disposal: A.
View the MSDS for this product
Selumetinib, also known as AZD6244, is a specific MEK1/2 inhibitor with an IC50 value of 14 nM against purified MEK1. Selumetinib also demonstrated a significant anti-angiogenic effect. "Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma."
Mol. Cancer Ther. 6: 138-146 (2007). Selumetinib and the mTOR inhibitor rapamycin had synergistic inhibitory effects on the growth of BxPC-3 and MIA PaCa-2 pancreatic cancers in vivo. Chang, Q., et al. "Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models." Cancer Biol. Ther. 8: 1893-1901 (2009).