上海叶舟生物科技有限公司

 Selumetinib, Free Base
  • Selumetinib, Free Base
  • Selumetinib, Free Base

    参考价格: ¥6444.00
    品  牌:LC
    产品型号:S-4490 (500 mg)
    所在地区:上海
    上架时间:2012年09月27日
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    Selumetinib, Free Base
    名称:原装进口| Selumetinib, Free Base
    产地:LC
    货号:S-4490
    规格:500 mg
    价格:6444
    储存温度说明
    Storage:  Store at or below -20 ºC. 
    Solubility:  Soluble in DMSO at 200 mg/mL; soluble in ethanol at 2.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Selumetinib, Free Base, >99%. Disposal:  A.
    产品其它相关介绍:
    View the MSDS for this product
    Selumetinib, also known as AZD6244, is a specific MEK1/2 inhibitor with an IC50 value of 14 nM against purified MEK1. Selumetinib also demonstrated a significant anti-angiogenic effect.  "Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma."
    Mol. Cancer Ther. 6:  138-146 (2007). Selumetinib and the mTOR inhibitor rapamycin had synergistic inhibitory effects on the growth of BxPC-3 and MIA PaCa-2 pancreatic cancers in vivo. Chang, Q., et al.  "Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models."  Cancer Biol. Ther. 8:  1893-1901 (2009).
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