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 Vemurafenib, Free Base
  • Vemurafenib, Free Base
  • Vemurafenib, Free Base

    参考价格: ¥17784.00
    品  牌:LC
    产品型号:V-2800 (500 mg)
    所在地区:上海
    上架时间:2012年09月27日
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    Vemurafenib, Free Base
    名称:原装进口| Vemurafenib, Free Base
    产地:LC
    货号:V-2800
    规格:500 mg
    价格:17784
    储存温度说明
    Storage:  Store at or below -20 ºC. 
    Solubility:  Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Vemurafenib, Free Base, >99%. Disposal:  A.
    产品其它相关介绍:
    View the MSDS for this product
    Vemurafenib inhibited the growth of B-Raf V600E-positive melanomas in vitro and in vivo.  Lee, J.T., et al.  "PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas."  Treatment of patients with metastatic melanoma that carry the V600E BRAF mutation with vemurafenib resulted in complete or partial tumor regression in the majority of patients. 
    Vemurafenib inhibited ERK1/2 in the highly sensitive BRAF(V600E/K) cells, while it activated the pathway in the (resistant) BRAF(WT) cells. Vemurafenib caused growth inhibition, G0/G1 arrest, and apoptosis in the sensitive cell lines. Using an IC50g cutoff of 1 µM, 13 of 35 cell lines tested showed sensitivity to vemurafenib, 16 were resistant, and 6 were intermediate in sensitivity. 
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