上海叶舟生物科技有限公司

 Everolimus  原装
  • Everolimus  原装
  • Everolimus 原装

    参考价格: ¥2655.0000
    品  牌:Affix
    产品型号:AF3030 (5 MG)
    所在地区:上海
    上架时间:2012/8/29 14:00:45
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    Everolimus  原装
    产品名称:Everolimus
    产品货号:Affix  AF3030
    产品规格:5 MG    
    Technical Data
    Chemical Name 3,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.; 40-O-(2-Hydroxyethyl)rapamycin; 42-O-(2-Hydroxy)ethyl rapamycin; Certican; RAD; RAD 001; SDZ-RAD; XIENCE V
    Biological Description Everolimus is a macrolide derived from Rapamycin, and shown to inhibit cell proliferation induced by growth factors. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Studies indicate that Everolimus is an mTOR inhibitor that displays high affinity toward the intracellular receptor FKBP12. The Everolimus-FKBP12 complex decreases the activity of the S6K1 and 4EBP by binding to mTOR
    Molecular Weight 958.2 daltons.
    Molecular Formula C53H83NO14
    Solubility Soluble in DMSO at 100 mg/mL; ethanol at 100 mg/mL; Not soluble in water.
    Purity >99 %
    Storage instructions Up to one week at 4°C or six months at -20°C.
    CAS No. 159351-69-6 
    References Anandappa, G., et al. 2010. Cancer Manag Res. 2: 61-70.