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  • Paclitaxel|紫杉醇|现货原装

    参考价格: ¥2180.00
    品  牌:Sigma
    产品型号:T7402 (5mg)
    所在地区:上海
    上架时间:2012年09月26日
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    Paclitaxel|紫杉醇|现货原装
    紫杉醇 Paclitaxel 现货供应
    产地:Sigma
    规格:5mg
    货号:T7402
    CAS号: 33069-62-4
    分子量: 853.91
    assay ≥95% (HPLC)
    form powder
    color white
    mp 213 °C (dec.)(lit.)
    产品说明:
    Biochem/physiol Actions
    Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).
    相关类型 Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, Antitumor Agents, Antiviral, Apoptosis Product Bundle, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cancer Research, Cell Biology, Chemical Structure Class, Drug andXenobiotic Metabolism, Interferes with DNA Synthesis, Mechanism of Action, Microtubule Inhibitors, Multi-Drug Resistance andDrug Metabolism, P, Spectrum of Activity, Substrates, Inducers, Inhibitors, Taxoides
    biological source from Taxus brevifolia