紫杉醇 Paclitaxel 现货供应
assay ≥95% （HPLC）
mp 213 °C （dec.）（lit.）
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin ａnd stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A （PKA） or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel （6α-OHP）.
相关类型 Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic ａnd Immunosuppressive Antibiotics, Antitumor Agents, Antiviral, Apoptosis Product Bundle, Apoptosis ａnd Cell Cycle, Bioactive Small Molecules, Cancer Research, Cell Biology, Chemical Structure Class, Drug andXenobiotic Metabolism, Interferes with DNA Synthesis, Mechanism of Action, Microtubule Inhibitors, Multi-Drug Resistance andDrug Metabolism, P, Spectrum of Activity, Substrates, Inducers, Inhibitors, Taxoides
biological source from Taxus brevifolia