Nucleoside antibiotic. Inhibits protein N-glycosylation by blocking the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Induces ER-stress following the inhibition of N-linked glycosylation. Arrests cell cycle in late G1. Unstable at acidic pH.
Formula: C38H62N4O16 (Tun B)
Long Term Storage: -20°C
MW: Avg. 840.0
Source: Isolated from Streptomyces lysosuperficus.
MI: 14: 9819
Purity: ≥99% (HPLC)
Appearance: White solid.
Hazard: VERY TOXIC.
Solubility: Soluble in DMSO (>10mg/ml) or ethanol (5mg/ml; warm).
Purity Detail: Mixture of tunicamycin A, B, C and D.
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.