A cAMP analog which is a potent and specific activator of cAMP-dependent protein kinase. It is cell permeable and is not significantly hydrolyzed by type I, II or III phosphodiesterases. It may be used to distinguish the cAMP- versus the cGMP-mediated signal transduction pathways. Surpasses the widely used but problematic dibutyryl-cAMP (Prod. No. BML-CN125) or 8-CTP-cAMP (Prod. No. BML-NA120).
Purity: ≥ 98% (HPLC)
Long Term Storage: -20°C
Formula: C12H10N2O5PSCl2 . Na
Appearance: White solid.
Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Solubility: Soluble in DMSO (167 mM), dimethyl formamide (167 mM), 96 % ethanol (167 mM), methanol (25 mM), water (25 mM) and aqueous buffers such as phostphate buffered saline (pH 7.4; 1.4 mM), 25 mM TRIS (pH 7.4-; 25 mM), 25 mM HEPES (pH 7.2; 35.7 mM) or Na2HPO4.