HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).
Purity: ≥98% (TLC)
Appearance: Colorless oil
Long Term Storage: -20°C
Solubility: Soluble in DMSO (>20mg/ml) or 100% ethanol (>20mg/ml)
Use/Stability: Solutions are stable for up to 3 months whn stored at -20°C. Avoid alkaline medium, pH>8.0
Biomol HNMPA-(AM)3 BML-EI248-0005 5 mg -20°C 1512
Biomol HNMPA-(AM)3 BML-EI248-0025 25 mg -20°C 6090