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4006816680-529
 AG-490|BML-EI272-0010
  • AG-490|BML-EI272-0010
  • AG-490|BML-EI272-0010

    参考价格: ¥1134.00
    品  牌:Biomol
    产品型号:10 mg
    所在地区:上海
    上架时间:2018年06月04日
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    AG-490|BML-EI272-0010
    产品名称:AG-490
    规格:10 mg
    货号:BML-EI272-0010
    厂商:Biomol
    产品介绍:
    AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src.
    It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
    Product Specification
    Formula: C17H14N2O3
    MW: 294.3
    CAS: 133550-30-8
    Purity: ≥98%
    Appearance: Tan solid.
    Long Term Storage: -20°C
    Handling: Protect from light.
    Solubility: Soluble in DMSO (30mg/ml), dimethyl formamide (40mg/ml) or 100% ethanol (10mg/ml).
    Biomol AG-490 BML-EI272-0010 10 mg -20°C 1134
    Biomol AG-490 BML-EI272-0050 50 mg -20°C 4536