产品名称：NEDP1 (human), pAb
Ub+1 is a novel form of ubiquitin that has been selectively observed in the brains of Alzheimers patients, including those with nonfamilial Alzheimers disease. Ub+1 is an efficient substrate for polyubiquitinylation in vitro and in transfected human cells. The resulting polyubiquitin chains are refractory to disassembly by deubiquitinating enzymes and potently inhibit the degradation of a polyubiquitinylated substrate by purified 26S proteasomes. Thus, expression of Ub+1 in aging brain could result in dominant inhibition of the Ub-proteasome system, leading to neuropathologic consequences.
Alternative Name: Ubiquitin+1
Long Term Storage: -20°C
Specificity: Recognizes human Ub+1.
Immunogen: Synthetic peptide corresponding to aa 76-95 of human Ub+1.
Application: Immunohistochemistry Western Blot (1:1000)
Optimal conditions must be determined individually for each application.
Formulation: Liquid. In PBS containing 10mM sodium azide.
Use/Stability: Store unopened vial at -20°C until required for use. The use of high quality antiserum-grade plastic or glass vials is recommended.. Dilute to working strength with phosphate buffered saline pH 7.2-7.4 and 1% normal goat serum (if a goat anti-rabbit IgG linker antibody is to be used). Store diluted antibody at 2-4°C (do not freeze) and use within 1 month.
Handling: After opening, prepare aliquots and store at -20°C.
Do not freeze.
Biomol Ub+1, pAb BML-PW9780-0025 25 ul -20°C 1365
Biomol Ub+1, pAb BML-PW9780-0100 100 ul -20°C 4767