Potent, cell permeable, inhibitor of PI(3)K (phosphoinositide 3-kinase) that acts on the ATP-binding site of the enzyme. Displays an IC50 of 1.4 µM and inhibits all isoforms equally in in vitro assays using purified PI 3-kinase. (p110α IC50=0.63µM)Inhibits Pim-1 kinase with IC50=4.0µM.Other kinases such as PKC, PKA, MAP kinase, S6 kinase, EGF receptor tyrosine kinase, c-src kinase, PI 4-kinase, diacylglycerol kinase or rabbit kidney ATPase are not inhibited at 50µM.
Alternative Name: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
Purity: ≥98% (TLC)
Long Term Storage: -20°C
Appearance: White to pale yellow solid.
Solubility: Soluble in DMSO (25mg/ml, warm), 100% ethanol (25mg/ml, warm) or methanol.
Use/Stability: Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Biomol LY 294002 BML-ST420-0005 5 mg -20°C 1365
Biomol LY 294002 BML-ST420-0025 25 mg -20°C 5481