Selectively inhibits monoacylglycerol (MAG) lipase (IC50=28µM) via a noncompetitive mechanism. Does not inhibit FAAH, DAG lipase or COX-2. URB-602 selectively raises levels of 2-arachidonoylglycerol with no change in anandamide concentrationsin cells and tissues. In the same way anandamide levels were markely elevated by the FAAH inhibitor URB597 at 1µM.
Purity: ≥98% (TLC)
Long Term Storage: Ambient
Appearance: Off-white solid.
Solubility: Soluble in DMSO (30mg/ml), 100% ethanol (10mg/ml) or dimethyl formamide (30mg/ml). also soluble in a 1:1 solution in DMSO:PBS, pH 7.2 (0.25mg/ml)
Use/Stability: Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Biomol URB-602 BML-EI348-0010 10 mg Ambient 924
Biomol URB-602 BML-EI348-0050 50 mg Ambient 3822