FL TRAP22O/DRIP2 PEPTIDE 100UM 原装_中国教育装备采购网

上海浩然生物技术有限公司

4008190228-0529
 FL TRAP22O/DRIP2 PEPTIDE 100UM 原装
  • FL TRAP22O/DRIP2 PEPTIDE 100UM 原装
  • FL TRAP22O/DRIP2 PEPTIDE 100UM 原装

    参考价格: ¥11200.00
    品  牌:invitrogen
    产品型号:11947011
    所在地区:上海
    上架时间:2018年08月16日
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    FL TRAP22O/DRIP2 PEPTIDE 100UM 原装
    产品: invitrogen
    货号: PV4549
    规格: 100 UL
    名称: FL TRAP22O/DRIP2 PEPTIDE 100UM
    LanthaScreen™ fluorescent nuclear receptor coregulator peptides contain known interaction motifs and are labeled with fluorescein. These peptides are matched and validated to complement the LanthaScreen™ TR-FRET Nuclear Receptor Coregulator Assays. Assays developed using these reagents enable primary or secondary screening of nuclear receptor agonists and/or antagonists.
    Contents and Storage:
    LanthaScreen™ fluorescent nuclear receptor coregulator peptides are supplied as 100 µM solutions in peptide-appropriate buffers. Store peptides at -20°C.
    How they work
    Ligand binding to nuclear receptors causes conformational changes in the receptor, resulting in a cascade of events, including dissociation of repressor proteins, association of coactivator proteins, and assembly of pol II and other transcriptional factors for activation of target genes. TR-FRET based assays can be developed using the LanthaScreen™ panel of fluorescein-labeled coregulator peptides to investigate conformational changes of nuclear receptors upon ligand binding, either by determining the affinity of ligand-bound receptor for different coregulator peptides, or by identifying additional agonists or antagonists via displacement or recruitment of a specific coregulator peptide. In the LanthaScreen™ TR-FRET RXR beta Coactivator Assay, a terbium (Tb)-labeled anti-GST antibody is used to indirectly label GSTtagged RXR beta protein. An agonist (9-cis Retinoic Acid) added to the receptor which, upon ligand binding, causes a conformational change resulting in recruitment of the Fl-D22 coactivator peptide .The binding of the fluorescent coregulator peptide to RXR beta causes an increase in the TR-FRET emission ratio .For Research Use Only. Not for any animal or human therapeutic or diagnostic use.