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 Epstein Barr virus Probe ISH Kit 原装正品
  • Epstein Barr virus Probe ISH Kit 原装正品
  • Epstein Barr virus Probe ISH Kit 原装正品

    参考价格: ¥11480.00
    品  牌:Vectorlabs
    产品型号:VP-Y177
    所在地区:上海
    上架时间:2018年08月28日
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    Epstein Barr virus Probe ISH Kit 原装正品
    产地: Vectorlabs
    货号: VP-Y177
    规格: 50 tests
    名称: Epstein Barr virus Probe ISH Kit
    This kit comprises proteinase K, detection probe, (negative) control probe, anti-fluorescein detection system, unlabeled control tissue sections, and 3 aminopropyltriethoxysilane (APES) treated slides. Each kit provides reagents sufficient for 50 tests.
    The Epstein-Barr virus (EBV) probe demonstrates cells latently infected with EBV. The probe hybridizes to abundantly expressed Epstein-Barr virus-encoded RNA (EBER) transcripts which are concentrated in the nuclei of latently infected cells. These transcripts are thought to block the activation of dsRNA-dependent eukaryotic initiation factor 2a (elF-2a) protein kinase DAI. In the absence of EBER, elF-2a inhibits cellular protein synthesis. The EBER molecules, therefore, promote both host cell survival and viral growth.
    EBV infection is associated with a variety of pathological conditions. The virus has been demonstrated by in situ hybridization in infectious mononucleosis, Burkitt’s lymphoma, the Reed Sternberg cells of Hodgkin’s disease and in nasopharyngeal carcinoma. In HIV infection EBV has also been demonstrated in primary CNS lymphomas and oral hairy leukoplakia lesions.