产品名称：CALPHOSTIN C, C. CLADOSPORIOIDES
Background Information: A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation
Molecular Weight: 790.8
Presentation: Light brown lyophilized solid.
Storage Conditions: Shipped at Ambient Temperature. Store at +2 - 8°C.
Empirical Formula: C44H38O14