Background Information: A potent and specific inhibitor of CaMK II (IC50 = 50 nM for both the total and Ca2+-independent CaMK II activity). Exhibits inhibitory activity across converged species, including rat brain, goldfish brain, and Drosophila (IC50 range 100-400 nM). Does not affect the activities of CaMK I, CaMK IV, CaMKK, PKA, or PKC. The peptide sequence corresponds to the inhibitory domain of CaMK IIN.
Empirical Formula: C136H240N44O39
Gene Symbol: CAMK2A, CAMK2B, CAMK2D, CAMK2G
Properties: Solubility: DMSO (5 mg/ml).
Presentation: Off-white solid. Supplied as a trifluoroacetate salt. Packaged under inert gas.
Molecular Weight: 3115.7
Storage Conditions: Shipped at Ambient Temperature. Store at -20°C.