产品名称：CDC25 PHOSPHATASE INHIBITOR I, BN82002
Background Information: A cell-permeable ortho-hydroxybenzylamino compound that displays antitumor properties. Acts as a potent, selective and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 µM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). Displays ~20-fold greater selectivity for CDC25 phosphatases over CD45 tyrosine phosphatase. Shown to delay cell cycle progression in vitro (IC50 = ~7.2-32.6 µM), and reduces tumor growth in athymic mice xenografted with the human pancreatic cells MIA PaCa-2 (15 mg/kg, i.p. route).
Empirical Formula: C19H25N3O4
Properties: Solubility: DMSO (10 mg/ml) or Ethanol (10 mg/ml).
Presentation: Brown solid. Packaged under inert gas.
Storage Conditions: Shipped at Ambient Temperature. Store at -20°C.