上海浩洋生物科技有限公司

 CDK4 INHIBITOR
  • CDK4 INHIBITOR
  • CDK4 INHIBITOR

    参考价格: ¥1555.00
    品  牌:merck
    产品型号:219476-1MG (1MG)
    所在地区:上海
    上架时间:2013年04月23日
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    CDK4 INHIBITOR
    产品名称:CDK4 INHIBITOR
    产品货号:219476-1MG
    产品价格:¥1555
    产品规格:1MG
    Background Information: A cell-permeable, unsymmetrical indolocarbazole compound that displays antiproliferative properties. Acts as a potent, selective, reversible and ATP-competitive inhibitor of Cdk4/D1 (IC50 = 76 nM). It inhibits the activity of other Cdk’s only at much higher concentrations (IC50 = 520 nM and 2.1 µM for Cdk2/E and Cdk1/B, respectively) and shows little activity towards CaMKII, PKA, or GSK-3β (IC50 ≥ 12.4 µM). Shown to inhibit tumor cells growth (IC50 < 3.0 µM in HCT-116 and NCI-H460 cells) by blocking Rb phosphorylation and inducing G1 cell cycle arrest.
    Empirical Formula: C20H10BrN3O2
    Gene Symbol: CDK4
    Properties: Solubility: DMSO (1 mg/ml).
    Presentation: Yellow solid. Packaged under inert gas.
    Molecular Weight: 404.2
    Storage Conditions: Shipped at Ambient Temperature. Store at +2 - 8°C.