产品名称：CFTR-F508DEL CORRECTOR, KM11060
Background Information: A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060.
Purity: ≥97% by HPLC
Empirical Formula: C19H17Cl2N3O2S
Presentation: White solid. Packaged under inert gas.
Molecular Weight: 422.3
Storage Conditions: Shipped at Ambient Temperature. Store at +2 - 8°C.