Background Information: A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC50 = 5 nM). Blocks EGF-mediated growth in A431 cells. Inhibits proliferation of EGFR or c-ErbB2 expressing cells (IC50 = 31-125 nM) by covalently binding to the EGFR.
Properties: Solubility: DMSO (200 mg/ml).
Molecular Weight: 381.2
Presentation: Pale yellow solid. Packaged under inert gas.
Empirical Formula: C18H13BrN4O
Storage Conditions: Shipped at Ambient Temperature. Store at -20°C.